MicroRNA-125b overexpression in pseudoexfoliation syndrome
نویسندگان
چکیده
منابع مشابه
Pseudoexfoliation Syndrome in Diabetic Patients
OBJECTIVE: Pseudoexfoliation syndrome (PEX) leads to some problems in the eye surgery specially cataract surgery. As the prevalence of eye problems is high in diabetic patients, we meant to assess the prevalence of PEX in diabetic patients. MATERIALS AND METHODS: In this cross-sectional study, 400 type 2 diabetic patients aged 50 or above who referred to Yazd Diabetes Research Center were sele...
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MicroRNA (miR)-125b expression is modulated in macrophages in response to stimulatory cues. In this study, we report a functional role of miR-125b in macrophages. We found that miR-125b is enriched in macrophages compared with lymphoid cells and whole immune tissues. Enforced expression of miR-125b drives macrophages to adapt an activated morphology that is accompanied by increased costimulator...
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MicroRNA miR-125b has been implicated in several kinds of leukemia. The chromosomal translocation t(2;11)(p21;q23) found in patients with myelodysplasia and acute myeloid leukemia leads to an overexpression of miR-125b of up to 90-fold normal. Moreover, miR-125b is also up-regulated in patients with B-cell acute lymphoblastic leukemia carrying the t(11;14)(q24;q32) translocation. To decipher th...
متن کاملPseudoexfoliation Syndrome
Pseudoexfoliation (PXF) syndrome is a well-recognized clinical entity of considerable clinical significance. It is associated with poor mydriasis, cataracts with weak zonular support, secondary glaucoma and possibly with biochemical abnormalities, such as elevated homocysteine and systemic diseases involving the cardiovascular and central nervous system. There have also been some recent studies...
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Background: MicroRNAs (miRNAs) are noncoding RNAs that control the expression of their target mRNAs. It affects cancer cell proliferation and apoptosis as oncogenes or tumor suppressors. Dysregulation of miRNAs expression leads to the development of various cancers. Therefore, for the first time in this field, this study investigated the effect of overexpression of microRNA-630 on the Jurkat ce...
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ژورنال
عنوان ژورنال: Advances in Clinical and Experimental Medicine
سال: 2020
ISSN: 1899-5276
DOI: 10.17219/acem/123623